VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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The value of evidence in the decision-making process for reimbursement of pharmacogenetic dosing of warfarinJanžič, Andrej ; Locatelli, Igor ; Kos, Mitja, 1973-Background: After early clinical trials that evaluated pharmacogenetic (PG) algorithms, many healthcare payers were reluctant to cover this technology and, consequently, PG dosing of warfarin could ... not be translated into clinical practice. Objective: The aim of this study was to estimate the value of upgrading evidence relating to PG dosing of warfarin from the healthcare payer perspective. Methods: Randomized controlled trials (RCTs) that evaluated PG dosing of warfarin were identified through a systematic literature search, and their findings were combined by a cumulative meta-analysis. A health economic model was used to estimate economic outcomes and to calculate the expected value of perfect information (EVPI) as a measure of the value of clinical trials for decision makers. Results: Nine RCTs were identified and included in our analysis. The estimated difference in the percentage of time in the therapeutic range was 5.6 percentage points in 2007, decreasing to 4.3 percentage points when all studies were included. At a reimbursement price of EUR160 per PG testing, the EVPI for the clinical benefit was estimated at EUR80 and EUR90 per patient in 2007 and 2014, respectively. A reduction in the price of PG testing to EUR40, which was observed in this period, resulted in an EVPI of EUR3 per patient. Conclusions: The estimated cumulative effect of PG dosing has remained similar since 2007, but additional evidence has contributed to a more precise estimation. While these variations should not affect the reimbursement decision, a large decline in the cost of PG testing in recent years calls for reconsideration.Vir: American journal of cardiovascular drugs. - ISSN 1175-3277 (Vol. 17, iss. 5, 2017, str. 399-408)Vrsta gradiva - članek, sestavni delLeto - 2017Jezik - angleškiCOBISS.SI-ID - 4330865
Avtor
Janžič, Andrej |
Locatelli, Igor |
Kos, Mitja, 1973-
Teme
varfarin |
farmakogenetika |
meta analiza
vir: American journal of cardiovascular drugs. - ISSN 1175-3277 (Vol. 17, iss. 5, 2017, str. 399-408)
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Janžič, Andrej | 32798 |
Locatelli, Igor | 24399 |
Kos, Mitja, 1973- | 20374 |
Vir: Osebne bibliografije
in: SICRIS
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