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  • Alternative affinity ligands for immunoglobulins
    Kruljec, Nika ; Bratkovič, Tomaž, farmacevt, 1978-
    The demand for recombinant therapeutic antibodies and Fc-fusion proteins is expected to increase in the years to come. Hence, extensive efforts are concentrated on improving the downstream ... processing. In particular, the development of better-affinity chromatography matrices, supporting robust time- and cost-effective antibody purification, is warranted. With the advances in molecular design and high-throughput screening approaches from chemical and biological combinatorial libraries, novel affinity ligands representing alternatives to bacterial immunoglobulin (Ig)-binding proteins have entered the scene. Here, we review the design, development, and properties of diverse classes of alternative antibody-binding ligands, ranging from engineered versions of Ig-binding proteins, to artificial binding proteins, peptides, aptamers, and synthetic small-molecular-weight compounds. We also provide examples of applications for the novel affinity matrices in chromatography and beyond.
    Vir: Bioconjugate chemistry. - ISSN 1043-1802 (Vol. 28, no. 8, 2017, str. 2009-2030)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 4362609

    Povezava(-e):

    http://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.7b00335
    DOI

vir: Bioconjugate chemistry. - ISSN 1043-1802 (Vol. 28, no. 8, 2017, str. 2009-2030)
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