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  • QSAR models for reproductive toxicity and endocrine disruption activity
    Novič, Marjana ; Vračko, Marjan
    Reproductive toxicity is an important regulatory endpoint, which is required in registration procedures of chemicals used for different purposes (for example pesticides). The in vivo tests are ... expensive, time consuming and require large numbers of animals, which must be sacrificed. Therefore an effort is ongoing to develop alternative In vitro and in silico methods to evaluate reproductive toxicity. In this review we describe some modeling approaches. In the first example we describe the CAESAR model for prediction of reproductive toxicity; the second example shows a classification model for endocrine disruption potential based on counter propagation artificial neural networks; the third example shows a modeling of relative binding affinity to rat estrogen receptor, and the fourth one shows a receptor dependent modeling experiment.
    Vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 15, no. 3, 2010, str. 1987-1999)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 4378138

    Povezava(-e):

    http://www.mdpi.com/1420-3049/15/3/1987/pdf
    DOI

vir: Molecules [Elektronski vir]. - ISSN 1420-3049 (Vol. 15, no. 3, 2010, str. 1987-1999)
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