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  • The physical state of indomethacin confined to nanometer dimensions
    Ukmar Godec, Tina ...
    Mesoporus silicates are currently widely studied as carriers for controlled drug delivery applications. Although many research groups focus mainly on drugrelease profiles, there are only a few ... studies investigating the physical state of confined drugs. However, it is firmly established that the structure of the incorporated drug is directly related to the release kinetics and thus,the biological response of the drug. In order to understand and control the release of the drug, it is crucial to know the physical state of the confined matter. Herein we present some results of our investigations of the structure and dynamics of a, pand y crystal forms of indomethacin (IMC) and IMC confined in mesoporous silicates using thermal and sorption analysis, XRPDand SS-NMR. Since IMC behaves thermally as a crystalline phase, and at thesame time its NMR spectral properties are clearly those of a glass, the physical state of confined IMC cannot be unambiguously defined. The measured proton spin-Iattice relaxation times have shown that the dynamical behavior strongly depends on pore size and interactions with the silica walls.
    Vrsta gradiva - prispevek na konferenci
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 4496410