VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Harnessing the untapped potential of NOD ligands for cancer immunotherapy
    Nabergoj, Sanja ; Mlinarič-Raščan, Irena ; Jakopin, Žiga
    In the last decade, cancer immunotherapy has emerged as an effective alternative to traditional therapies such as chemotherapy and radiation. In contrast to the latter, cancer immunotherapy has the ... potential to distinguish between cancer and healthy cells, and thus to avoid severe and intolerable side%effects, since the cancer cells are effectively eliminated by stimulated immune cells. The cytosolic nucleotide%binding oligomerization domains 1 and 2 receptors (NOD1 and NOD2) are important components of the innate immune system and constitute interesting targets in terms of strengthening the immune response against cancer cells. Many NOD ligands have been synthesized, in particular NOD2 agonists that exhibit favorable immunostimulatory and anticancer activity. Among them, mifamurtide has already been approved in Europe by the European Medicine Agency for treating patients with osteosarcoma in combination with chemotherapy after complete surgical removal of the primary tumor. This review is focused on NOD receptors as promising targets in cancer immunotherapy as well as summarizing current knowledge of the various NOD ligands exhibiting antitumor and even antimetastatic activity in vitro and in vivo.
    Vir: Medicinal research reviews. - ISSN 1098-1128 (Vol. 39, iss. 5, 2019, str. 1447-1484)
    Vrsta gradiva - članek, sestavni del
    Leto - 2019
    Jezik - angleški
    COBISS.SI-ID - 4641905

    Povezava(-e):

    https://onlinelibrary.wiley.com/doi/full/10.1002/med.21557
    Repozitorij Univerze v Ljubljani – RUL
    DOI

vir: Medicinal research reviews. - ISSN 1098-1128 (Vol. 39, iss. 5, 2019, str. 1447-1484)
loading ...
loading ...
loading ...

Vnos na polico