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13-cis-retinoic acid and bone densityKocijančič, MilenaBACKGROUND. 13-Cis-retinoic acid has an influence on bone in patients on long-term treatment as well as on short-term treatment. The presence of skeletal abnormalities after the treatment was ... established by roentgenologic and scintigraphic examinations. We wanted to know whether a 6-month course of low-dose 13-cis-retinoic acid has a clinically important influence on bone density in men with severe acne. METHODS. We examined 15 men with severe acne before and after treatment with 13-cis-retinoic acid by dual-photon absorptiometry of the lumbar spine. RESULTS. The mean increase in bone density was 3.0 percent (95 percent confidence interval 1.3-4.5), which is normal for the period from puberty to late twenties. Bone density increased in 13 of our 15 patients. CONCLUSIONS. As shown by this highly sensitive modern densitometric method, 13-cis-retinoic acid has no clinically important influence on bone density in male patients with severe acne.Vir: International journal of dermatology. - ISSN 0011-9059 (Let. 34, št. 10, 1995, str. 733-734)Vrsta gradiva - članek, sestavni delLeto - 1995Jezik - angleškiCOBISS.SI-ID - 4683225
Avtor
Kocijančič, Milena
Teme
Acne vulgaris |
Drug therapy |
Bone and bones |
Drug effects |
Bone density |
Drug effects |
Isotretinoin |
Therapeutic use |
Absorptiometry, photon |
Adolescence |
Adult |
Aging |
Bone and bones |
Radiography |
Gadolinium |
Diagnostic use |
Isotretinoin |
Administration and dosage |
Lumbar vertebrae |
Drug effects |
Radiography |
Puberty |
Radioisotopes |
Diagnostic use
Vnos na polico
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