VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Vrednotenje proteoliznih encimov in njihovih inhibitorjev kot prognostičnih pokazateljev karcinoma dojke : magistrsko delo
    Levičar, Nataša
    Proteolytic enzymes have been proposed as the new potentail biological prognostic factors for breast cancer patients. Determination of their concentrations in primary tumours may facilitate decision ... about treatment of breast cancer patients, following the removal of the tumor. Previous investigations have shown, that increased expression of cysteine proteinases cathepsins B and L (CatB and CatL) and urokinase-type plasminogen activator (uPA) in tumor, compared to normal breast tissue, were associated with breast tumour progression. Similarly, altered levels of their endogenous inhibitors stefins A and B (StA and StB) and plasminogen activator inhibitor-1 (PAI-1) were found in malignant tumours. We determined the levels of CatB, CatL, StA, StB, uPA and PAI-1 in 150 primary invasive ductal carcinoma and 83 matched control breast tissues by measuring activity and by ELISA. Proteinases and their inhibitors were found 2-12 fold increased in tumour tissue compared withthe controls. Good correlation was found between tumour levels of CatB andCatL (r=0.65). Weak correlation was found between uPA and PAI-1 (r=0.41) and very low correlation between CatB and uPA (r=0.32). Cathepsins and stefinswere not related with standard clinical and histopathological factors indicating tumour progression. In contrast, elevated levels of uPA correlated well with the histological grade (p<0.00) and with positive ER (p<0.01), whilePAI-1 correlated with all histopahological factors, except tumour size. We evaluated and compared the prognostic impact of all these biological factors. Increased levels of uPA and PAI-1 had the most significant impact on shorter disease-free survival (DFS) (p<0.00, p<0.02, respectively) and overallsurvival (OS) (p,0.00, p,0.05, respevtively). (Abstract truncated at 2000 characters.)
    Vrsta gradiva - magistrsko delo ; neleposlovje za odrasle
    Založništvo in izdelava - Ljubljana : [N. Levičar], 1999
    Jezik - slovenski
    COBISS.SI-ID - 470863

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 1 izv.
Nacionalni inštitut za biologijo in BF, Oddelek za biologijo, Ljubljana Ljubljana BFBNIB v čitalnico 1 izv.
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