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  • Surface binding studies of spin-labelled piroxicam by electron paramagnetic resonance
    Kristl, Julijana ...
    Piroxicam is a highly potent anti-inflammatory and analgetically active drug the bioavailability of which is affected by its low solubillity and dissolution rate. To modify its dissolution ... characteristics, solvent deposits of piroxicam and spinlabelled piroxicam (4-hydroxy-2-methyl-N-(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)-2H-1,2-ben zoth iazine-3-carboxamide 1,1-dioxide) on silica (amorphous non porous silicon dioxide) or on sodium chloride crystals were prepared. Electron paramagnetic resonance (EPR) spectra reveal the distribution and packing of molecules on the surface of the carriers. For concentration ranges up to 3.10* mol g*silica(>0.06 molecules nm -2)the relative populations of agglomerates and sparingly populated regions were detected, including the possible rearrangement of deposited piroxicam molecules upon heat treatment. The relative dissolution rates conform with the population of the agglomerated fraction of piroxicam.
    Vir: Colloids and surfaces. A, Physicochemical and Engineering Aspects. - ISSN 0927-7757 (Vol. 72, 1993, str. 307-312)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 1993
    Jezik - angleški
    COBISS.SI-ID - 4721

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