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  • Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis [Elektronski vir]
    Kodrič, Klemen, biomedicinec ...
    Receptor activator of nuclear factor kappaB ligand (RANKL) plays a crucial role in bone metabolism. RANKL gene misregulation has been implicated in several bone and cancer diseases. Here, we aimed to ... identify novel transcription regulators of RANKL expression. We discovered that transcription factors, sex-determining region Y (SRY) and c-Myb, regulate RANKL expression. We demonstrated that c-Myb increases and male-specific SRY decreases RANKL expression through direct binding to its 5'-proximal promoter. These results are corroborated by the gene expression in human bone samples. In osteoporotic men, expression of RANKL is 17-fold higher, which correlates with the drastically reduced expression (200-fold) of Sry, suggesting that in osteoporotic men, the upregulation of RANKL is caused by a decrease of Sry. In healthy men, the expression of RANKL is 20% higher than that in healthy women. Our data suggest that gender differences in RANKL expression and bone quality could be due to the sex-specific transcription factor SRY.
    Vir: Experimental and molecular medicine. - ISSN 2092-6413 (Vol. 51, no. 8, Aug. 2019, str. 1-16)
    Vrsta gradiva - e-članek
    Leto - 2019
    Jezik - angleški
    COBISS.SI-ID - 4766321

    Povezava(-e):

    https://www.nature.com/articles/s12276-019-0294-3
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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