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  • Suicide ideators and attempters with schizophrenia : the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants
    Božina, Nada ...
    Aim: To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. Methods: The study included 519 ... subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). Results: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N =174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of LA allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SLG; 3) No difference was found between the three clinical groups inthe 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (LALG,SLA) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution. Conclusion: The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.
    Vir: Journal of Psychiatric Research. - ISSN 0022-3956 (Vol. 46, iss. 6, 18. apr. 2012, str. 767-773)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 48636002

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0022395612000908

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    DOI

vir: Journal of Psychiatric Research. - ISSN 0022-3956 (Vol. 46, iss. 6, 18. apr. 2012, str. 767-773)
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