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  • The effect of equinatoxin II on nerve and muscle
    Horvat-Žnidaršič, Irena ; Šuput, Dušan
    ǂThe ǂeffect of equinatoxin II on the eicitability of nerve and muscle membrane was examined. Neuromuscular transmission was assessed indirectly by measurement of isometric muscle contractions. ... Membrane currents and potentials were measured by means of vaseline-gap voltage-clamp and current-clamp methods on single isolated skeletal muscle fibres. 10 nM equinatorin II induces spontaneous twitches of skeletal muscle fibres provided that the neuromuscular junction remains intact. In curarized muscles and by use of higher final concentrations of equinatorin II prolonged contractures were observed. This may be etplained by a pore formation in the muscle membrane. An increase in the leakage conductance of skeletal muscle fibres supports this hypothesis.
    Vir: Pflügers Archiv : european journal of physiology. - ISSN 0031-6768 (Let. 431, št. 6, suppl. 2, 1996, str. R279-80)
    Vrsta gradiva - članek, sestavni del
    Leto - 1996
    Jezik - angleški
    COBISS.SI-ID - 4868825