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  • Efficient synthesis of hydroxy-substituted 2-aminobenzo[d]thiazole-6-carboxylic acid derivatives as new building blocks in drug discovery [Elektronski vir]
    Durcik, Martina ...
    Benzo[d]thiazole is widely used in synthetic and medicinal chemistry, and it is a component of many compounds and drugs that have several different bioactivities. Herein, we describe an elegant ... pathway for synthesis of methyl 4- and 5-hydroxy-2-amino-benzo[d]thiazole-6-carboxylates as building blocks that can be substituted at four different positions on the bicycle and thus offer the possibility to thoroughly explore the chemical space around the molecule studied as a ligand for the chosen target. A series of 12 new compounds was prepared using the described methods and Williamson ether synthesis.
    Vir: ACS omega [Elektronski vir]. - ISSN 2470-1343 (Vol. 5, iss. 14, 2020, str. 8305-8311)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 4897137

    Povezava(-e):

    https://pubs.acs.org/doi/10.1021/acsomega.0c00768
    https://pubs.acs.org/doi/pdf/10.1021/acsomega.0c00768
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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