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  • Patient-reported outcome of solifenacin treatment among women experiencing urinary urgency and urgency incontinence
    But, Igor ...
    Objective: To evaluate treatment success and tolerability of solifenacin among women with urinary urgency (UU) and urgency urinary incontinence (UUI). Methods: In a prospective, observational, ... multicenter pilot study in Slovenia and Croatia, 100 women with UU and UUI were enrolled between January 2011 and July 2011. Patients received 5 mg of solifenacin once daily for 12 weeks and completed a 3-day bladder diary, urgency questionnaire, Urogenital Distress Inventory (UDI), and Incontinence Impact Questionnaire (IIQ). Results: Overall, 91 women completed 12 weeks of treatment. Severity, frequency, and bother of UU significantly had decreased at weeks 4 and 12 (P < 0.001). Improvement in UU led to an improvement in mean IIQ score: a reduction in UU frequency had the greatest impact (P = 0.006). The mean treatment success rate was 74.2% (by visual analog score) and was closely related to the mean change in irritative UDI score (r = 0.39; P < 0.001). Treatment success was greatest for patient perception of intensity of urgency scale (PPIUS; P = 0.003), UU bother (P = 0.017), and micturition frequency (P < 0.026). Dry mouth occurred in 35.2% of women at 4 weeks, and 27.7% at week 12. Conclusion: Solifenacin treatment was effective and well-tolerated among women with UU and UUI. All overactive bladder symptoms had improved by week 12.
    Vir: International journal of gynaecology & obstetrics. - ISSN 0020-7292 (Vol. 124, issue 1, 2014, str. 19-23)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 4941375

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    DOI

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