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  • Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
    Marušič, Maja ...
    We herein report on the formation and high-resolution NMR solution-state structure determination of a G-quadruplex adopted by d[G3ATG3ACACAG4ACG3] comprised of four G-tracts with the third one ... consisting of four guanines that are intervened with non-G streches of different lengths. A single intramolecular antiparallel (3+1) G-quadruplex exhibits three stacked G-quartets connected with propeller, diagonal and edgewise loops of different lengths. The propeller and edgewise loops are well structured, whereas the longer diagonal loop is more flexible. To the best of our knowledge, this is the first highresolution G-quadruplex structure where all of the three main loop types are present.
    Vir: Nucleic acids research. - ISSN 0305-1048 (Vol. 40, no. 14, 2012, str. 6946-6956)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 5032474
    DOI

vir: Nucleic acids research. - ISSN 0305-1048 (Vol. 40, no. 14, 2012, str. 6946-6956)
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