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  • Prediction of mutagenicity, carcinogenicity, developmental toxicity, and skin sensitisation with caesar program for a set of conazoles = Napovedi mutagenosti, karcenogenosti, razvojne toksičnosti in kožne občutljivosti za niz konazolov
    Bolčič Tavčar, Mateja, 1980- ; Vračko, Marjan
    This article presents models to predict mutagenicity, carcinogenicity, developmental toxicity, and skin sensitisation for a set of 27 conazoles. The predictions were performed with the program ... package CAESAR, which is available on the Internet. The CAESAR programs were developed to support the European Community Regulation on chemicals and their safe use (REACH) and follow the OECD principles for (Q)SAR models used for regulatory purposes. The programs provide a number of information, including a binary classifi cation of a compound as toxic or non-toxic and information on similar compounds from the model's training sets (similarity sets). In this study we analysed conazole sets using principal component analysis (PCA). The predictions were compared to the currently valid classification of these substances in the European Union (EU) or to the classification proposed at expert meetings of the Pesticide Risk Assessment and Peer Review (PRAPeR) group. The predicted classification for mutagenicity was in good agreement with regulatory classification, the predictions for carcinogenicity and developmental toxicity showed some discrepancy in particular cases, while the predictions for skin sensitisation showed even greater discrepancy
    Vir: Arhiv za higijenu rada i toksikologiju = Archives of industrial hygiene and toxicology. - ISSN 0004-1254 (Vol. 63, no. 3, 2012, str. 283-292)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 5075226

    Povezava(-e):

    http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=129304
    DOI

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