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  • NMR screening for putative repellents targeting Odorant Binding Proteins (OBPs) of the mosquito Anopheles gambiae, the primary vector for malaria : [oral presentation]
    Potamitis, Konstantinos ...
    The mosquito Anopheles gambiae (Agam) is the major vector of malaria in sub-Saharan Africa. Although the role of olfaction in Agam host detection has been demonstrated, little is known about the ... interactions of ligands and OBPs that can produce specific odor-related responses in vivo. Our goal is the development of environmentally friendly mosquito repellents, which may ultimately contribute to reduction of mosquito biting and disease transmission. This study focuses on the NMR screening of commercially available ligands, which have shown insect repellent properties on AgamOBP1 protein target. The employed NMR screening schemes, Saturation Transfer Difference (STD) and tr-NOESY has been validated by probing the molecular recognition of N,N-diethyl-3-methylbenzamide (DEET) by OBP1 in accordance withthe recently published crystal complex. Carvacrol (5-isopropyl-2-methylphenol), known for its mosquito repellent activity, was ranked among the identified hits for the studied target. STD competition studies have indicated that OBP1 is able to bind both of them.
    Vir: Advanced mass spectrometric and NMR methods : abstract book (Str. 23)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 5100058

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