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  • ATP regulates sodium channel kinetics in pancreatic islet beta cells
    Zou, Na ...
    Pancreatic beta cells act as glucose sensors, in which intracellular ATP ([ATP](i)) are altered with glucose concentration change. The characterization of voltage-gated sodium channels under ... different [ATP](i) remains unclear. Here, we demonstrated that increasing [ATP](i) within a certain range of concentrations (2-8 mM) significantly enhanced the voltage-gated sodium channel currents, compared with 2 mM cytosolic ATP. This enhancement was attenuated by even high intracellular ATP (12 mM). Furthermore, elevated ATP modulated the sodium channel kinetics in a dose-dependent manner. Increased [ATP](i) shifted both the current-voltage curve and the voltage-dependent inactivation curve of sodium channel to the right. Finally, the sodium channel recovery from inactivation was significantly faster when the intracellular ATP level was increased, especially in 8 mM [ATP](i), which is an attainable concentration by the high glucose stimulation. In summary, our data suggested that elevated cytosolic ATP enhanced the activity of Na(+) channels, which may play essential roles in modulating cell excitability and insulin release when blood glucose concentration increases.
    Vir: The journal of membrane biology. - ISSN 0022-2631 (Vol. 246, iss. 2, 2013, str. 101-107)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 512288568

    Povezava(-e):

    http://link.springer.com/content/pdf/10.1007%2Fs00232-012-9506-7.pdf
    Digitalna knjižnica Univerze v Mariboru – DKUM
    DOI

vir: The journal of membrane biology. - ISSN 0022-2631 (Vol. 246, iss. 2, 2013, str. 101-107)
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