VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Clostridium difficile binary toxin CDT : mechanism, epidemiology, and potential clinical importance
    Gerding, Dale N. ...
    Binary toxin (CDT) is frequently observed in Clostridium difficile strains associated with increased severity of C. difficile infection (CDI). CDT belongs to the family of binary ADP-ribosylating ... toxins consisting of two separate toxin components: CDTa, the enzymatic ADP-ribosyltransferase which modifies actin, and CDTb which binds to host cells and translocates CDTa into the cytosol. CDTb is activated by serine proteases and binds to lipolysis stimulated lipoprotein receptor. ADP-ribosylation induces depolymerization of the actin cytoskeleton. Toxin-induced actin depolymerization also produces microtubule-based membrane protrusions which form a network on epithelial cells and increase bacterial adherence. Multiple clinical studies indicate an association between binary toxin genes in C. difficile and increased 30-d CDI mortality independent of PCR ribotype. Further studies including measures of binary toxin in stool, analyses of CDI mortality caused by CDT-producing strains, and examination of the relationship of CDT expression to TcdA and TcdB toxin variants and PCR ribotypes are needed.
    Vir: Gut microbes. - ISSN 1949-0976 (Vol. 5, Iss. 1, 2014, str. 1-13)
    Vrsta gradiva - članek, sestavni del
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 512368184

    Povezava(-e):

    https://www.landesbioscience.com/journals/gutmicrobes/article/26854/
    DOI

vir: Gut microbes. - ISSN 1949-0976 (Vol. 5, Iss. 1, 2014, str. 1-13)
loading ...
loading ...
loading ...

Vnos na polico