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A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruptionCosta, Cecília Leite ...The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered ... from a cancer patient in Brazil that died from severe diarrhea. A polyphasic approach assigned a new PCR-ribotype and PFGE macrorestriction pattern to strain ICC-45, which is toxigenic (tcdA+, tcdB+ and ctdB+) and classified as ST41 from MLST Clade 2 and toxinotype IXb. Strain ICC-45 encodes for a variant TcdB that induces a distinct CPE in agreement with its toxinotype. Unlike epidemic NAP1/027 strains, which are also classified to MLST Clade 2, strain ICC-45 is susceptible to fluoroquinolones and does not overproduce toxins TcdA and TcdB. However, supernatants from strain ICC-45 and a NAP1/027 strain produced similar expression of pro-inflammatory cytokines, epithelial damage, and oxidative stress response in the mouse ileal loop model. These results highlight inflammation and oxidative stress as common features in the pathogenesis of C. difficile Clade 2 strains. Finally, this work contributes to the description of differences in virulence among various C. difficile strains.Vir: Anaerobe. - ISSN 1075-9964 (Vol. 40, 2016, str. 76-84)Vrsta gradiva - članek, sestavni delLeto - 2016Jezik - angleškiCOBISS.SI-ID - 512620856
Avtor
Costa, Cecília Leite |
López-Ureña, Diana |
Oliveira Assis, Thiago de |
Ribeiro, Ronaldo A. |
Silveira Silva, Rodrigo Otávio |
Rupnik, Maja, 1967- |
Wilcox, Mark, mikrobiolog |
Carvalho, Alex Fiorini de |
Carmo, Anderson Oliveira do |
Martins Dias, Adriana Abalen |
Carvalho, Cibele Barreto Mano de
Teme
Clostridium difficile |
MLST Clade 2 |
Variant toxin B |
Inflammation |
Oxidative stress response
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Costa, Cecília Leite | ![]() |
López-Ureña, Diana | ![]() |
Oliveira Assis, Thiago de | ![]() |
Ribeiro, Ronaldo A. | ![]() |
Silveira Silva, Rodrigo Otávio | ![]() |
Rupnik, Maja, 1967- | 12278 |
Wilcox, Mark, mikrobiolog | ![]() |
Carvalho, Alex Fiorini de | ![]() |
Carmo, Anderson Oliveira do | ![]() |
Martins Dias, Adriana Abalen | ![]() |
Carvalho, Cibele Barreto Mano de | ![]() |
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