VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Multilayered polysaccharide nanofilms for controlled delivery of pentoxifylline and possible treatment of chronic venous ulceration [Elektronski vir]
    Stana, Jan ...
    Local drug delivery systems made from non-toxic polysaccharide nanofilms have an enormous potential in wound care. A detailed understanding of the structural, surface, physicochemical and cytotoxic ... properties of such systems is crucial to design clinically efficacious materials. Herein, we fabricated polysaccharide-based nanofilms onto either a 2D model (SiO2 and Au-sensors) or on non-woven alginate 3D substrates using an alternating assembly of N,N,N-trimethylchitosan (TMC) and alginic acid (ALG) prepared by a spin-assisted layer-by-layer (LbL) technique. These TMC/ALG multi-layered nanofilms are used for a uniform encapsulation and controlled release of pentoxifylline (PTX), a potent anti-inflammatory drug for treatment of the chronic venous ulceration. We show a tailorable film growth and mass, morphology, as well as surface properties (charge, hydrophilicity, porosity) of the assembled nanofilms through control of the coating during the spin-assisted assembly. The uniform distribution of the encapsulated PTX in the TMC/ALG nanofilms is preserved even with when the amount of the incorporated PTX increases. The PTX release mechanism from the model and real systems is studied in detail and is very comparable for both systems. Finally, different cell based assays illustrated the potential of the TMC/ALG multilayer system in wound care (e.g., treatment chronic venous ulceration) applications, including a decrease of TNF-[alpha] secretion, a common indicator of inflammation.
    Vir: Biomacromolecules [Elektronski vir]. - ISSN 1526-4602 (Vol. 18, iss. 9, 2017, str. 2732-2746)
    Vrsta gradiva - e-članek
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 512736312

    Povezava(-e):

    http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00523
    DOI

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