VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • p300 expression is related to high-risk human papillomavirus infections and severity of cervical intraepithelial neoplasia but not to viral or disease outcomes in a longitudinal setting
    Syrjänen, Stina ...
    To evaluate the role of the expression of the transcription factor p300 as an independent predictor of high-risk human papillomavirus (HR-HPV) infections and outcome of the cervical disease. Cervical ... biopsy samples taken at enrolment from 225 women of the Latin American Screening study cohort were analyzed for p300 using immunohistochemistry to assess its value as predictor of (a) cervical intraepithelial neoplasia (CIN) grade, and (b) HR-HPV at baseline, as well as (c) outcomes of HR-HPV infections, and (d) development ofincident CIN as surrogate endpoints of progressive disease. There was a significant linear trend in increasing upregulation (=pattern shift) of p300 (P=0.0001) in parallel with increasing grade of CIN. When dichotomized (normalžmoderately increase vs. strong-intense), upregulated p300 expression predicted CIN3+ with odds ratio=4.16 (95% confidence intervalČ 1.95-8.86) (P=0.0001) and CIN2+ with odds ratio=3.48 (95% confidence intervalČ 1.86-6.48)(P=0.0001). p300 was upregulated more often in HR-HPV+ lesions than in those remaining negative. Semiquantitative viral loads were also directly related to upregulation of p300 (P=0.036), but p300 was not a significant predictor of disease progression to either CIN1+ or CIN2+. p300 expression wasupregulated in CIN lesions and related to detection and viral load of HR-HPV but not to their outcome or to incident CIN.
    Vir: International journal of gynecological pathology. - ISSN 0277-1691 (Vol. 29, issue 2, Mar 2010, str. 135-145)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 516166937
    DOI

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