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Statin plus ezetimibe treatment in clinical practice : the SI-(SPEC) (Slovenia (SI) statin plus ezetimibe in cholesterol treatment) monitoring of clinical practice studyFras, Zlatko ; Mikhaidilis, Dimitri P.Background: Poor results from lipid-lowering therapy are mainly due to inadequate dosing and increased adverse effects with high-dose statin monotherapy or drug combinations. Objectives: The SI-SPECT ... (Slovenia (SI) Statin Plus Ezetimibe in Cholesterol Treatment) study evaluated the effectiveness of either ezetimibe (EZE) 10?mg as monotherapy or co-administered with on-going statin treatment (S + EZE) in clinical practice. Design and methods: A total of 1053 dyslipidaemic patients (52% men,age 60.3 years, 42.9% with CHD, 32.0% with diabetes mellitus and 69.6% with hypertension) were enrolled. The majority (n=986; 93.6%) were treated with EZE as "add-on" to their already prescribed statin, the rest only received EZE (n=67). Main outcome measures: Baseline lipid levels were compared with those obtained 16 weeks after initiating treatment. Results: Total (TC) and low density lipoprotein cholesterol (LDL-C), as well as triglycerides (TG) decreased significantly with S + EZE (by 25.3%, 31.4% and 28.9%, respectively; p < 0.0001 for all comparisons), while monotherapy with EZE resulted in a decrease of 20.8% for TC ( p < 0.0001), 28.0% for LDL-C (p < 0.0001) and 28.8% for TG ( p = 0.016). At the end of the study 43.9% of patients achieved target TC (< 5.0 mmol/L for primary prevention and < 4.5 mmol/L for secondary prevention), 50.5% target LDL-C (< 3.0 mmol/L for primary prevention and < 2.5 mmol/L for secondary prevention) and 61.6% targetTG (< 2.0 mmol/L). The overall incidence of adverse effects during the treatment period, and probably related to EZE use, was low (n = 6, 0.6% of patients). Conclusions: (1) S + EZE combination therapy was effective and safe irrespective of the statin used, (2) the S + EZE combination resulted in significantly more patients reaching their recommended target lipid levels and(3) the lipid-lowering efficacy of EZE in monotherapy as well as of the S + EZE combination was related to initial lipid values. The much greater decrease of TG than expected could be, at least in part, due to better control/compliance regarding diet and drug treatment during the study and adherence to the need for an overnight fast before sampling.Vir: Current medical research and opinion. - ISSN 0300-7995 (Vol. 24, no. 9, 2008, str. 2467-2476)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 516482329
Avtor
Fras, Zlatko |
Mikhaidilis, Dimitri P.
Teme
Dyslipidaemia |
Ezetimibe |
LDL-cholesterol |
Low density lipoprotein (LDL) |
Statin |
Triglycerides
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Fras, Zlatko | 11685 |
Mikhaidilis, Dimitri P. | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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