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  • Designing multivalent probes for tunable superselective targeting [Elektronski vir]
    Dubacheva, Galina V. ...
    Specific targeting is common in biology and is a key challenge in nanomedicine. It was recently demonstrated that multivalent probes can selectively target surfaces with a defined density of surface ... binding sites. Here we show, using a combination of experiments and simulations on multivalent polymers, that such "superselective" binding can be tuned through the design of the multivalent probe, to target a desired density of binding sites. We develop an analytical model that provides simple yet quantitative predictions to tune the polymer's superselective binding properties by its molecular characteristics such as size, valency, and affinity. This work opens up a route toward the rational design of multivalent probes with defined superselective targeting properties for practical applications, and provides mechanistic insight into the regulation of multivalent interactions in biology. To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affainity of individual CD44-hyaluronan interacions.
    Vir: Proceedings of the National Academy of Sciences of the United States of America [Elektronski vir]. - ISSN 1091-6490 (Vol. 112, iss. 18, 2015, str. 5579-5584)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 525409561

    Povezava(-e):

    http://www.pnas.org/content/112/18/5579.full.pdf
    DOI

Vnos na polico