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  • A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes [Elektronski vir]
    Lee, Ernest Y. ...
    We examine how the interferon production of plasmacytoid dendritic cells is amplified by the self-assembly of liquid%crystalline antimicrobial peptide/DNA complexes. These specialized dendritic cells ... are important for host defense because they quickly release large quantities of type I interferons in response to infection. However, their aberrant activation is also correlated with autoimmune diseases such as psoriasis and lupus. In this review, we will describe howpolyelectrolyte self-assembly and the statistical mechanics ofmultivalent interactions contribute to this process. In a more general compass, we provide an interesting conceptual corrective to the common notion in molecular biology of a dichotomy between specific interactions and non-specific interactions, and show examples where one can construct exquisitely specific interactions using non-specific interactions.
    Vir: Advances in colloid and interface science. - ISSN 0001-8686 (Vol. 232, Jun. 2016, str. 17-24)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 526561305

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0001868616300471
    DOI

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