VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy [Elektronski vir] : a systematic review
    Zottel, Alja ...
    Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal ... proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and therapeutic targets. Among them, GFAP, has gained most attention as potential diagnostic biomarker, while vimentin and microtubules are considered as prospective therapeutic targets. Microtubules represent one of the best anti-cancer targets due to their critical role in cell proliferation. Despite testing in clinical trials, the efficiency of taxanes, epothilones, vinca-domain binding drugs, colchicine-domain binding drugs and %-tubulin binding drugs remains to be confirmed. Moreover, tumor treating field that disrupts microtubules draw attention because of its high efficiency and is called "the fourth cancer treatment modality". Thereby, because of the involvement of cytoskeleton in key physiological and pathological processes, its therapeutic potential in glioblastoma is currently extensively investigated.
    Vir: Critical Reviews in Oncology. Hematology [Elektronski vir]. - ISSN 1879-0461 (Vol. 160, 2021, str. 1-13)
    Vrsta gradiva - e-članek
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 54458627

    Povezava(-e):

    https://www.sciencedirect.com/science/article/pii/S1040842821000718?via%3Dihub
    Repozitorij Univerze v Ljubljani – RUL
    DOI

Vnos na polico