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Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma [Elektronski vir] : an international multicenter studyBrčić, Luka ...Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic ... significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.Vir: Translational lung cancer research [Elektronski vir]. - ISSN 2226-4477 (Vol. 10, no. 4, Apr. 2021, str. 1594-1607)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2021Jezik - angleškiCOBISS.SI-ID - 56719619
Avtor
Brčić, Luka |
Klikovits, Thomas |
Megyesfalvi, Zsolt |
Mosleh, Berta |
Sinn, Katharina |
Hritcu, Richard |
Laszlo, Viktoria |
Čufer, Tanja, 1955- |
Rozman, Aleš, 1973- |
Kern, Izidor |
Mohorčič, Katja, 1978-
Teme
Mesothelioma |
Anatomy and histology |
Analysis |
Prognosis |
Mezoteliom |
Anatomija in histologija |
Analiza |
Prognoza |
maligni plevralni mezoteliom |
ligand programirane celične smrti 1 |
programirana celična smrt 1 |
PD-L1 |
malignant pleural mesothelioma |
programmed death-ligand 1 |
programmed cell death 1 |
PD-L1
Vnos na polico
Trajna povezava
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Faktor vpliva
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Brčić, Luka | |
Klikovits, Thomas | |
Megyesfalvi, Zsolt | |
Mosleh, Berta | |
Sinn, Katharina | |
Hritcu, Richard | |
Laszlo, Viktoria | |
Čufer, Tanja, 1955- | 12179 |
Rozman, Aleš, 1973- | 25177 |
Kern, Izidor | 15781 |
Mohorčič, Katja, 1978- | 30985 |
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