VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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Assessing different temporal scales of calcium dynamics in networks of beta cell populations [Elektronski vir]Zmazek, Jan ...Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent oscillations of membrane potential and intracellular calcium concentration that presumably drive the ... pulsatile exocytosis of insulin. Their rhythmic activity is multimodal, resulting from networked feedback interactions of various oscillatory subsystems, such as the glycolytic, mitochondrial, and electrical/calcium components. How these oscillatory modules interact and affect the collective cellular activity, which is a prerequisite for proper hormone release, is incompletely understood. In the present work, we combined advanced confocal Ca2+ imaging in fresh mouse pancreas tissue slices with time series analysis and network science approaches to unveil the glucose-dependent characteristics of different oscillatory components on both the intra- and inter-cellular level. Our results reveal an interrelationship between the metabolically driven low-frequency component and the electrically driven high-frequency component, with the latter exhibiting the highest bursting rates around the peaks of the slow component and the lowest around the nadirs. Moreover, the activity, as well as the average synchronicity of the fast component, considerably increased with increasing stimulatory glucose concentration, whereas the stimulation level did not affect any of these parameters in the slow component domain. Remarkably, in both dynamical components, the average correlation decreased similarly with intercellular distance, which implies that intercellular communication affects the synchronicity of both types of oscillations. To explore the intra-islet synchronization patterns in more detail, we constructed functional connectivity maps. The subsequent comparison of network characteristics of different oscillatory components showed more locally clustered and segregated networks of fast oscillatory activity, while the slow oscillations were more global, resulting in several long-range connections and a more cohesive structure. Besides the structural differences, we found a relatively weak relationship between the fast and slow network layer, which suggests that different synchronization mechanisms shape the collective cellular activity in islets, a finding which has to be kept in mind in future studies employing different oscillations for constructing networks.Vir: Frontiers in physiology [Elektronski vir]. - ISSN 1664-042X (Vol. 12, Mar. 2021, 16 str.)Vrsta gradiva - e-članekLeto - 2021Jezik - angleškiCOBISS.SI-ID - 56986115
Avtor
Zmazek, Jan |
Skelin, Maša |
Markovič, Rene |
Dolenšek, Jurij |
Marhl, Marko |
Stožer, Andraž |
Gosak, Marko, 1982-
Teme
Biofizika |
Langerhansovi otočki |
islets of Langerhans |
beta cell network |
calcium oscillations |
multimodal activity analysis |
confocal imaging |
functional connectivity |
multiplex network
Avtor | Zmazek, Jan ... |
Naslov | Assessing different temporal scales of calcium dynamics in networks of beta cell populations [Elektronski vir] |
Datum objave | |
COBISS.SI-ID | 56986115 |
Verzija objave v repozitoriju | Ni določeno |
Licenca objave v repozitoriju | Ni določeno |
Embargo | Ni določeno |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
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Celične in tkivne mreže | P3-0396-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Biofizika polimerov, membran, gelov, koloidov in celic | P1-0055-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Infrastrukturna dejavnost Univerze v Mariboru | I0-0029-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Vloga cikličnega adenozin monofosfata v normalni fiziologiji celic beta in med razvojem sladkorne bolezni tipa 2 | J3-9289-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Vloga ionskih kanalov TRPM3 in TRPM5 pri uravnavanju mrežne aktivnosti v otočkih trebušne slinavke | N3-0048-2016 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Celice beta med razvojem in remisijo z dieto povzročene sladkorne bolezni | N3-0133-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.612233/full |
https://dk.um.si/IzpisGradiva.php?id=89004 |
Vnos na polico
Trajna povezava
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Zmazek, Jan | 52033 |
Skelin, Maša | 29565 |
Markovič, Rene | 34480 |
Dolenšek, Jurij | 23415 |
Marhl, Marko | 13159 |
Stožer, Andraž | 32132 |
Gosak, Marko, 1982- | 28405 |
Vir: Osebne bibliografije
in: SICRIS
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