VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Mur ligases inhibitors with azastilbene scaffold [Elektronski vir] : Expanding the structure-activity relationship
    Hrast, Martina ...
    Antibiotic resistance represents one of the biggest public health challenges in the last few years. Mur ligases (MurC-MurF) are involved in the synthesis of UDP-N-acetylmuramyl-pentapeptide, the main ... building block of bacterial peptidoglycan polymer. They are essential for the survival of bacteria and therefore important antibacterial targets. We report herein the synthesis and structure-activity relationships of Mur ligases inhibitors with an azastilbene scaffold. Several compounds showed promising inhibitory potencies against multiple ligases and one compound also possessed moderate antibacterial activity. These results represent a solid ground for further development and optimization of structurally novel antimicrobial agents to combat the rising bacterial resistance.
    Vir: Bioorganic & Medicinal Chemistry Letters [Elektronski vir]. - ISSN 1464-3405 (Vol. 40, 2021, art. 127966, str. 1-5)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 57984515

    Povezava(-e):

    https://www.sciencedirect.com/science/article/abs/pii/S0960894X2100192X?via%3Dihub
    DOI

Vnos na polico