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  • Neurotropic viruses, astrocytes, and COVID-19 [Elektronski vir]
    Tavčar Verdev, Petra ...
    At the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) was discovered in China, causing a new coronavirus disease, termed COVID-19 by the WHO on February 11, 2020. At ... the time of this paper (January 31, 2021), more than 100 million cases have been recorded, which have claimed over 2 million lives worldwide. The most important clinical presentation of COVID-19 is severe pneumonia; however, many patients present various neurological symptoms, ranging from loss of olfaction, nausea, dizziness, and headache to encephalopathy and stroke, with a high prevalence of inflammatory central nervous system (CNS) syndromes. SARS-CoV-2 may also target the respiratory center in the brainstem and cause silent hypoxemia. However, the neurotropic mechanism(s) by which SARS-CoV-2 affects the CNS remain(s) unclear. In this paper, we first address the involvement of astrocytes in COVID-19 and then elucidate the present knowledge on SARS-CoV-2 as a neurotropic virus as well as several other neurotropic flaviviruses (with a particular emphasis on the West Nile virus, tick-borne encephalitis virus, and Zika virus) to highlight the neurotropic mechanisms that target astroglial cells in the CNS. These key homeostasis-providing cells in the CNS exhibit many functions that act as a favorable milieu for virus replication and possibly a favorable environment for SARS-CoV-2 as well. The role of astrocytes in COVID- 19 pathology, related to aging and neurodegenerative disorders, and environmental factors, is discussed. Understanding these mechanisms is key to better understanding the pathophysiology of COVID-19 and for developing new strategies to mitigate the neurotropic manifestations of COVID-19.
    Vir: Frontiers in cellular neuroscience. - ISSN 1662-5102 (Vol. 15, Apr. 2021, str. 1-14)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 58875651

    Povezava(-e):

    https://www.frontiersin.org/articles/10.3389/fncel.2021.662578/full
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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