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Electrochemotherapy in mucosal cancer of the head and neck [Elektronski vir] : a systematic reviewStrojan, Primož ...Electrochemotherapy (ECT) is a local ablative treatment that is based on the reversible electroporation and intracellular accumulation of hydrophilic drug molecules, which greatly increases their ... cytotoxicity. In mucosal head and neck cancer (HNC), experience with ECT is limited due to the poor accessibility of tumors. In order to review the experience with ECT in mucosal HNC, we undertook a systematic review of the literature. In 22 articles, published between 1998 and 2020, 16 studies with 164 patients were described. Curative and palliative intent treatment were given to 36 (22%) and 128 patients (78%), respectively. The majority of tumors were squamous cell carcinomas (79.3%) and located in the oral cavity (62.8%). In the curative intent group, complete response after one ECT treatment was achieved in 80.5% of the patients, and in the palliative intent group, the objective (complete and partial) response rate was 73.1% (31.2% and 41.9%). No serious adverse events were reported during or soon after ECT and late effects were rare (19 events in 17 patients). The quality-of-life assessments did not show a significant deterioration at 12 months post-ECT. Provided these preliminary data are confirmed in randomized controlled trials, ECT may be an interesting treatment option in selected patients with HNC not amenable to standard local treatment.Vir: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 13, no. 6, 2021, str. [1-10])Vrsta gradiva - e-članekLeto - 2021Jezik - angleškiCOBISS.SI-ID - 61662211
Avtor
Strojan, Primož |
Grošelj, Aleš |
Serša, Gregor |
Plaschke, Christina Caroline |
Vermorken, Jan B. |
Nuyts, Sandra |
De Bree, Remco |
Eisbruch, Avraham |
Mendenhall, William M. |
Smee, Robert |
Ferlito, Alfio
Teme
elektrokemoterapija |
rak glave in vratu |
mukozni rak |
electrochemotherapy |
head and neck cancer |
mucosal cancer
Avtor | Strojan, Primož ... |
Naslov | Electrochemotherapy in mucosal cancer of the head and neck [Elektronski vir] : a systematic review |
Datum objave | 2021-03-12 |
COBISS.SI-ID | 61662211 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Rak glave in vratu - analiza bioloških značilnosti in poskus izboljšanja zdravljenja | P3-0307-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999968/ |
https://dirros.openscience.si/IzpisGradiva.php?id=15581 |
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Strojan, Primož | 14576 |
Grošelj, Aleš | 36605 |
Serša, Gregor | 08800 |
Plaschke, Christina Caroline | |
Vermorken, Jan B. | |
Nuyts, Sandra | |
De Bree, Remco | |
Eisbruch, Avraham | |
Mendenhall, William M. | |
Smee, Robert | |
Ferlito, Alfio |
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