-
Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activityGuzelj, Samo ...We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro ... and in vivo adjuvant properties. We identified two promising compounds: 68, a potent nanomolar in vitro NOD2 agonist, and the more lipophilic 75, which shows superior adjuvant activity in vivo. Both compounds had immunostimulatory effects on peripheral blood mononuclear cells at the protein and transcriptional levels, and augmented dendritic-cell-mediated activation of T cells, while 75 additionally enhanced the cytotoxic activity of peripheral blood mononuclear cells against malignant cells. The C18 lipophilic tail of 75 is identified as a pivotal structural element that confers in vivo adjuvant activity in conjunction with a liposomal delivery system. Accordingly, liposome-encapsulated 75 showed promising adjuvant activity in mice, surpassing that of muramyl dipeptide, while achieving a more balanced Th1/Th2 immune response, thus highlighting its potential as a vaccine adjuvant.Vir: Journal of medicinal chemistry. - ISSN 0022-2623 (Vol. 64, iss. 11, 2021, str. 7809-7838)Vrsta gradiva - članek, sestavni delLeto - 2021Jezik - angleškiCOBISS.SI-ID - 64930051
Avtor
Guzelj, Samo |
Nabergoj, Sanja |
Gobec, Martina, 1983- |
Pajk, Stane, 1983- |
Klančič, Veronika |
Slütter, Bram |
Frkanec, Ruža |
Štimac, Adela |
Šket, Primož, 1977- |
Plavec, Janez |
Mlinarič-Raščan, Irena |
Jakopin, Žiga
Teme
Farmacevtska kemija |
Peptidi |
Toksičnost |
Organske spojine |
reakcijski produkti |
reaction products |
peptides and proteins |
cells |
organic compounds |
toxicity
Avtor | Guzelj, Samo ... |
Naslov | Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity |
Datum objave | 2021-05-29 |
COBISS.SI-ID | 64930051 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Razvoj agonistov receptorja NOD2 ter dualnih NOD2/TLR7 agonističnih konjugatov kot novih adjuvansov za cepiva | J3-9256-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
---|
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00644 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=141424 |
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Guzelj, Samo | 52379 |
Nabergoj, Sanja | 38165 |
Gobec, Martina, 1983- | 32034 |
Pajk, Stane, 1983- | 28861 |
Klančič, Veronika | 54787 |
Slütter, Bram | |
Frkanec, Ruža | |
Štimac, Adela | |
Šket, Primož, 1977- | 22575 |
Plavec, Janez | 10082 |
Mlinarič-Raščan, Irena | 12443 |
Jakopin, Žiga | 26496 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.