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  • European registry of babies born to mothers with antiphospholipid syndrome
    Mekinian, Arsene ...
    Objectives This study aimed to describe the long-term outcome and immunological status of children born to mothers with antiphospholipid syndrome, to determine the factors responsible for childhood ... abnormalities, and to correlate the child's immunological profile with their mothers. Methods A prospective follow-up of a European multicentre cohort was conducted. The follow-up consisted of clinical examination, growth data, neurodevelopmental milestones and antiphospholipid antibodies (APL) screening.Children were examined at 3, 9, 24 months and 5 years. Results 134children were analysed (female sex in 65 cases, birth weight 3000Ž500 g, height 48Ž3 cm). Sixteen per cent had a preterm birth (<37 weeks; n=22), and 14% weighted less than 2500 g at birth (n=19). Neonatal complications were noted in 18 cases (13%), with five infections (4%). During the 5-year follow-up, no thrombosis or systemic lupus erythematosus (SLE) was noted. Fourchildren displayed behavioural abnormalities, which consisted of autism, hyperactive behaviour, feeding disorder with language delay and axial hypotonywith psychomotor delay. At birth lupus anticoagulant was present in four (4%), anticardiolipin antibodies (ACL) IgG in 18 (16%), anti-Ž2 glycoprotein-I (anti-Ž2GPI) IgG/M in 16 (15%) and three (3%), respectively. ACL IgG and anti-Ž2GPI disappeared at 6 months in nine (17%) and nine (18%), whereas APL persisted in 10% of children. ACL and anti-Ž2GPI IgG were correlated with the same mother's antibodies before 6 months of age (p<0.05). Conclusion Despite the presence of APL in children, thrombosis or SLE were not observed. The presence of neurodevelopmental abnormalities seems to be more important in these children, and could justify long-term follow-up.
    Vir: Annals of the Rheumatic Diseases. - ISSN 0003-4967 (Vol. 72, iss. 2, feb. 2013, Str. 217-222)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 658860

    Povezava(-e):

    http://ard.bmj.com/content/72/2/217.full.pdf+html
    DOI

vir: Annals of the Rheumatic Diseases. - ISSN 0003-4967 (Vol. 72, iss. 2, feb. 2013, Str. 217-222)
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