VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Novel strategies to expand supercharged NK cells with augmented capacity to withstand inactivation by tumors [Elektronski vir]
    Jewett, Anahid ...
    Natural killer (NK) cells are the main immune effectors with the ability to mediate selection and differentiation of a number of different cancer stem cells/undifferentiated or poorly differentiated ... tumors via lysis, and secreted or membrane bound IFN-[gamma] and TNF-[alpha]. Tumor differentiation byNKcells leads to growth inhibition and curtailment of tumor metastasis. In this chapter, we present an overview of our recent and past findings on the biology and significance of NK cells in the selection/differentiation of stem-like tumors using in vitro and in vivo studies conducted in the NSG and humanized-BLT mice and those of cancer patients. In addition, we discuss the significance of heightened NK cell function in a great variety of gene knockout mice, providing a potential rationale for the mechanisms of the activation of NK cells in these animals. Moreover, we report on the recent advances in NK cell expansion and therapeutic delivery, and discuss the superiority of allogeneic
    Vir: Successes and challenges of NK Immunotherapy [Elektronski vir] : breaking tolerance to cancer resistance (Str. 101-119)
    Vrsta gradiva - e-članek
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 66200579

    Povezava(-e):

    https://www.sciencedirect.com/science/article/pii/B9780128243756000059

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    DOI

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