Selpercatinib in RET fusion-positive non-small-cell lung cancer (SIREN) [Elektronski vir] : a retrospective analysis of patients treated through an access programIllini, Oliver ...Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic ... activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Methods: A retrospective efficacy and safety analysis was performed on data from RET fusion-positive NSCLC patients who participated in a selpercatinib access program (named patient protocol) between August 2019 and January 2021. Results: Data from 50 patients with RET fusion-positive advanced NSCLC treated with selpercatinib at 27 centers in 12 countries was analyzed. Most patients were Non-Asian (90%), female (60%), never-smokers (74%), with a median age of 65 years (range, 38-89). 32% of the patients had known brain metastasis at the time of selpercatinib treatment. Overall, 13 patients were treatment-naïve, while 37 were pretreated with a median of three lines of therapy (range, 1-8). The objective response rate (ORR) was 68% [95% confidence interval (CI), 53-81] in the overall population. The disease control rate was 92%. The median progression-free survival was 15.6 months (95% CI, 8.8-22.4) after a median follow-up of 9 months. In patients with measurable brain metastases (n=8) intracranial ORR reached 100%. In total, 88% of patients experienced treatment-related adverse events (TRAEs), a large majority of them being grade 1 or 2. The most common grade >/=3 TRAEs were increased liver enzyme levels (in 10% of patients), prolonged QTc time (4%), abdominal pain (4%), hypertension (4%), and fatigue/asthenia (4%). None of patients discontinued selpercatinib treatment for safety reasons. No new safety concerns were observed, nor where there any treatment-related death. Conclusions: In this real-world setting, the selective RET-inhibitor selpercatinib demonstrated durable systemic and intracranial antitumor activity in RET fusion-positive NSCLC and was well tolerated.Vir: Therapeutic advances in medical oncology. - ISSN 1758-8359 (Vol. 13, 2021, str. 1-17)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2021Jezik - angleškiCOBISS.SI-ID - 66935555
Illini, Oliver | Hochmair, Maximilian J | Fabikan, Hannah | Weinlinger, Christoph | Tufman, Amanda | Swalduz, Aurélie | Lamberg, Kristina | Hashemi, Sayed M. S. | Huemer, Florian | Vikström, Anders | Mohorčič, Katja, 1978-
Carcinoma, non-small cell lung | Drug therapy | Genetics | Molecular targeted therapy | Nedrobnocelični karcinom pljuč | Terapija z zdravili | Genetika | Molekularna tarčna terapija | podatki iz resničnega življenja | selperactinib | tarčna terapija | zaviralci tirozinskih kinaz | real-world data | selpercatinib | targeted therapy | tyrosine kinase inhibitor
Vnos na polico
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Baze podatkov, v katerih je revija indeksirana
|Ime baze podatkov||Področje||Leto|
|Povezave do osebnih bibliografij avtorjev||Povezave do podatkov o raziskovalcih v sistemu SICRIS|
|Hochmair, Maximilian J|
|Hashemi, Sayed M. S.|
|Mohorčič, Katja, 1978-||30985|
Izberite prevzemno mesto:
Gesla v Splošnem geslovniku COBISS
Prosimo, počakajte trenutek.