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  • Beta-blocker propranolol modulates decision urgency during sequential information gathering [Elektronski vir]
    Hauser, Tobias U. ...
    Arbitrating between timely choice and extended information gathering is critical for effective decision making. Aberrant information gathering behaviour is thought to be a feature of psychiatric ... disorders, such as schizophrenia and obsessive-compulsive disorder, but we know little about the underlying neurocognitive control mechanisms. In a double-blind placebo-controlled drug study involving 60 healthy human subjects (30 female), we examined the effects of noradrenaline and dopamine antagonism on information gathering during performance of an information sampling task. We show that modulating noradrenaline function with 40 mg of the beta-blocker propranolol leads to decreased information gathering behaviour. Modulating dopamine function via a single dose of 400 mg amisulpride revealed some effects that were intermediate between those of propranolol and placebo. Using a Bayesian computational model, we show sampling behaviour is best explained by inclusion of a nonlinear urgency signal that promotes commitment to an early decision. Noradrenaline blockade promotes the expression of this decision-related urgency signal during information gathering. We discuss the findings with respect to psychopathological conditions that are linked to aberrant information gathering.
    Vir: The journal of neuroscience [Elektronski vir]. - ISSN 1529-2401 (Vol. 38, iss. 32, 8 Aug. 2018, str. 7170-7178)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2018
    Jezik - angleški
    COBISS.SI-ID - 67350882

    Povezava(-e):

    https://doi.org/10.1523/JNEUROSCI.0192-18.2018
    http://www.jneurosci.org/content/early/2018/07/13/JNEUROSCI.0192-18.2018
    DOI

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