VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Ultrasound-guided autologous myoblast injections into the extrinsic urethral sphincter : tissue engineering for the treatment of stress urinary incontinence
    Blaganje, Mija ; Lukanovič, Adolf
    Introduction and hypothesis Limitations of the existing treatment methods for stress urinary incontinence (SUI) have encouraged investigation of new therapeutic approaches in the field of ... regenerative medicine. Enabled by tissue engineering technology safety, feasibility and efficacy of ultrasound-guided intrasphincteric autologous myoblast implantation to treat SUI presented in the accompanying video were assessed in a pilot study of 38 women. Methods Following upper arm muscle biopsy, autologous myoblast suspension was injected into the extrinsic urethral sphincter under transurethral ultrasound visualization. Functional electrical stimulation (FES) was used postoperatively to possibly enhance cell integration. Objectiveand subjective parameters were compared at 6 weeks, 3 months, and 6 months postoperatively. Results The tissue harvest, laboratory tissue processing, and myoblast implantation were successful in all 38 patients. No serious adverse events were reported through the course of the study. Objective and subjective measurements collected at baseline were significantlyimproved at 6 weeks postoperatively. Additional improvement or a plateau was observed at 3 and 6 months postoperatively, not being negatively influenced by discontinuation of FES. Of the patients, 23.7 % considered theirSUI cured, and 52.6 % reported improvement at 6 months; 95 % would recommend this treatment to others. Conclusions Intrasphincteric ultrasound-guided autologous myoblast injection for SUI is feasible. This simple to perform and well-tolerated minimally invasive procedure safely produced promising initial results.
    Vir: International urogynecology journal. - ISSN 0937-3462 (Vol. 24, iss. 4, apr. 2013, str. 533-535)
    Vrsta gradiva - članek, sestavni del
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 677292

    Povezava(-e):

    http://link.springer.com/article/10.1007%2Fs00192-012-1963-0
    DOI

vir: International urogynecology journal. - ISSN 0937-3462 (Vol. 24, iss. 4, apr. 2013, str. 533-535)
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