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  • Radioprotection of salivary glands by amifostine in high-dose radioiodine therapy investigated in a new rabbit animal model
    Hübner, Ralf-Harto ...
    Salivary gland damage following high-dose radioiodine treatment (HD-RIT) is a well known side effect. Since differentiated thyroid cancer (DTC) has a very good prognosis, the reduction of long-term ... side effect is of major interest. Therefore, the radioprotective effect of amifostine was investigated in a rabbit animal model. Quantitative salivary gland scintigraphy was performed on5 rabbits prior to and up to 3 months after HD-RIT applying 1 GBq I-131. Theuptake of Tc-99cm-pertechnetate was calculated as a measure of parenchymal function. Three animals received 200 mg/kg amifostine prior to HD-RIT, and twoserved as controls. Salivary glands were examined histopathologically. In two control rabbits HD-RIT significantly (p<0.001) reduced pertechnetate uptake by 63% and 46% in parotid and submandibular glands, respectively, and lipomatosis was found histopathologically. In contrast, in three rabbits treated with amifostine parenchymal function was not decreased significantly (p=0.953), and lipomatosis was negligible. In conclusion, salivary gland impairment induced by HD-RIT can be evaluated quantitatively by salivary glandscintigraphy in rabbits, and amifostine significantly reduced salivary gland damage induced by HD-RIT. These encouraging results need furtner evaluation in patients since in may help to increase the quality of life of patients with diffentiated thyroid cancer.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Let. 31, št. 3, 1997, str. 279-285)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - angleški
    COBISS.SI-ID - 7387097

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    Digitalna knjižnica Slovenije - dLib.si

vir: Radiology and oncology. - ISSN 1318-2099 (Let. 31, št. 3, 1997, str. 279-285)
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