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  • The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus [Elektronski vir]
    Lensen, Karel-Jan Dag François ...
    Objectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a ... draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of >6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4% vs. 88.9 %; p D 0.68). In total, 27% of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the Published by Copernicus Publications on behalf of EBJIS and MSIS. 314 K.-J. D. F. Lensen et al.: The efficacy of suppressive antibiotic treatment need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2% of cases, respectively. However, the sinus tract tended to close more often (42% vs. 13 %; p D 0.14), and a higher resolution of pain was observed (35% vs. 14 %; p D 0.22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed.
    Vir: Journal of bone and joint infection. - ISSN 2206-3552 (Letn. 6, 2021, Str. 313-319)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2021
    Jezik - angleški
    COBISS.SI-ID - 76208131

    Povezava(-e):

    https://doi.org/10.5194/jbji-6-313-2021

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    DOI

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