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  • In vivo učinki aktinoporinov, izoliranih iz Actiniae equinae = In vivo effects of actinoporins, isolated from Actinia equina
    Giacomelli, Valentina Otja
    The mechanism of action of the actinoporins, substances from the sea anemone Actinia equina, is by cationselective pore formation in the cellular membranesthat consequently cause cell lysis. The aim ... of the present study cause cell lysis. The aim of the present study was to investigate the mechanism of the toxicity of actinoporin equinatoxin I. In in vivo experimentsthe measurements of ECG (lead l), respiratory activity and arterialblood pressure were taken, the hematological and biochemical analysis of the blood samples were performed. The tisue samples were taken for pathomorphologic examination. After application of equinatoxin l there was a fall in the arterial pressure. A prominent bradycardia was followed by the phase of the relative tahycardia. During the bradycardia the amplitude of P waves was diminished and the P-Q interval was prolonged. Eventually ventricular extrasistoly developed and P waves disappeared. The tahypnoe was followed by the breathing cessation. In a while the animal started to breath and terminated again. The experimental animals died due to the cardio-respiratory arrest. The blood samples revealed haemolysis and hyperkalemia, fall of hematokrit and rise in potassium plasma concentration for four times. Pathomorphological examination showed pulmonary edema with hemorrhages and early necrosis of cardiomyocytes. The lethality of actinoporins is due to cardiorespiratory arrest. Equinatoxin l differentiates from the other actinoporins in the special acivity on the excitability of the atrium, as the P waves in ECG disappeared. The induced hyperkalemia was not sufficient to explain the lethality of the toxin. Equinatoxin l induces acute necrosis of myocardium. Together with pulmonary edema this is the most important mechanism that leads to the death of experimental animals.
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 36, št. 4, 1997, str. 437-464)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - slovenski
    COBISS.SI-ID - 7989209

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    Digitalna knjižnica Slovenije - dLib.si

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