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  • Pre-PTCA detection of hibernating myocardium
    Pust, Borut, 1938- ; Rutar, Viljem
    It was intention of the present study to find out whether in patients (n = 24) suffering from angina pectoris on-effort and having angiographically documented one-vessel coronary artery disease ... (CAD), improvement of postischemic left ventricular (LV) dysfunction (dueto reversibly hibernated poststenotic myocardium) after successful PTCA can be predicted by the effect of calcium antagonism during pre-PTCA invasive diagnostic study. Quantitative RAO 30 degree left cineventriculography was performed four times successively:as a control study, 30 min after oral nicardipine, 10 min after succcessful PTCA and 6 months after PTCA. Area - lenght method and mean relative hemiaxis shortening (X delta r%) method were used for assessment of LV global function and wall motion analysis of 48 poststenotic myocardial segments divided into 3 groups: hypokinetic noninfarcted, infarcted and normokinetic noninfarcted. Results: A close positive correlation (r = 0.88, p< 0.0001 r - 0.89, p < 0.0001) was demonstrated between post-nicardipine improvement (57 -+ 10% - 65 +- 11%, p < 0.00) on one side and immediately after successful PTCA (57 =- 10% - 62 =- 10%, p < 0.0005) and 6 months after successful PTCA (57 =- 10% - 64 =- 10%, p < 0.0001) improvement of LV ejectionfraction on the other side. The improvement of LV global ejection fraction after either intervention was mainly due to improved wall motion of poststenotic noninfarcted hypokinetic LV segments. The sensitivity of the nicardipine test for early and late after PTCA reversible global LV dysfunction was excellent (100% and 92%). Both, specificities (67% and 82%) and predictive values (79% and 87%) were high. In conclusion, using nicardipine test during pre-PTCA invasive diagnostic study, improvement of global LV function immediately and late after PTCA can be well predicted with excellent sensitivity.(Abstract truncated at 2000 characters)
    Vir: International Symposium on Cardiovascular Diseases held at Ljubljana, Slovenia, December 3 - 5, 1998 : proceedings of the 29th Memorial Meeting devoted to prof. dr. Janez Plečnik (Str. 61-69)
    Vrsta gradiva - prispevek na konferenci
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 8846297

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