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  • Proliferation and proliferation markers
    Cör, Andrej
    Cell proliferation is one of the most fundamental of biological processes. Cardiac myocytes were considered to be terminally differentiated cells that nolonger possess the capacity of undergoing DNA ... synthesis and mitotic division. In recent years, numerous quantitative morphological studies have provided strong supportive evidence that ventricular myocytes are not terminally differentiated cells, and myocyte cellular hyperplasia may constitute are not terminally differentiated cells, and myocyte cellular hyperplasia may constiute a significant component of ventricular remodelling in the adult human heart. Different methods for myocyte proliferation assessment have been used in those studies. This brief overview is intended toillustrate the advantages and disadvantages of the better known methods for assessing cellular proliferation in histopathological material of human hearts. An absolute requirement for pathologists is to have a clear understainding of the biology of proliferation markers. A single proliferationmarket can hardly be interpreted independently of others. Three types of markers are necesary to describe cell population kinetics: one measures the growth fraction (Ki-67, MIB-1,...), the second evaluates the cellcycle speed inarbitrary units (Ag-NORs) and the last assesses the S phase cells occurrence frequency (BrdU, PCNA,...) or mitosis frequency. Combining the three types of kinetic parameters may provide insight into still poorly understand myocyte proliferation.
    Vir: International Symposium on Cardiovascular Diseases held at Ljubljana, Slovenia, December 3 - 5, 1998 : proceedings of the 29th Memorial Meeting devoted to prof. dr. Janez Plečnik (Str. 363-370)
    Vrsta gradiva - prispevek na konferenci
    Leto - 1998
    Jezik - angleški
    COBISS.SI-ID - 8855257

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