VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Caracterisation par hybridation in situ des remaniements chromosomiques dans un glioblastome
    Bourgeois, C.A... ...
    Chromosomal rearrangements in a glioblastoma; site specificity? In a case of glioblastoma, the following karyotype was determined: 47, X, -Y + dt(1;9)(p21;p23), t(1;9)(p21;p23), +3, +7, der(9) ... t(Y;9)(q11;p21), -13, t(13;16)(p13, p11), dell(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1,9, 15, 16 and Y. Because, most of these chromosomes were implicated in the rearrangements, a detailed cytogenetic study was undertaken. This study included in situ hybridization of the satellite and alphoid DNAs of chromosomes 1, 9, 16 and Y combined with various chromosome banding methods (DA-DAPI, quinacrine mustard and R-banding). The data obtained, demonstrated that the breakpoints were always located outside the areas containing the satellite and alphoid DNAs. The situation observed here differs from that reported in breast cancers for which a high proportion of the breakpoints than those implicated in brest cancers. Thus, in cancers, chromosomal instabilities may result from several mechanisms.
    Vir: Bulletin du cancer. - ISSN 0007-4551 (Let. 81, 1994, str. 360-365)
    Vrsta gradiva - članek, sestavni del
    Leto - 1994
    Jezik - francoski
    COBISS.SI-ID - 90585

vir: Bulletin du cancer. - ISSN 0007-4551 (Let. 81, 1994, str. 360-365)
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