VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content
    Horvat, Simon ...
    A genome-wide quantitative trait locus (QTL) analysis was performed in a polygenic obesity mouse model resulting from a long-term selection experiment. The paternal lines were outbred lines ... divergently selected for 53 generations for high-fat (fat, F line) or low-fat (fean, L line) percentage (fat %) that differed five-hold in fat % at 14 weeks of age. An F2 population of 436 mice was used for the QTL analysis with 71 markers disributed across the genome. The analysis revealed significant QTLs Fob1 (for F-lineobesity QTL1), Fob2, Fob3 and Fob4, on Chromosomes (Chrs)2, 12, 15, and X, respectively. None of these QTLs map to regions of known single gene obesity mutations (Lepob, Leprdb, Cpefat, Ay, tub), though they map to regions of previously described obesity QTLs and candidate genes. The effects of Fob1, Fob3, Fob4 wer additive, and that of Fob2 was dominant. Fob2 also showed a significant female-specific effect. Fob1, Fob2, Fob3, and Fob4 explained 4.9%,19.5%, 14.4%, and 7.3% of the F2 phenotypic variance for fat%, respectively. This study identified four loci that contributed to the response to divergent selection and control a significant proportion of the difference in obesity between the F and L lines.
    Vir: Mammalian genome. - ISSN 0938-8990 (Vol. 11, 2000, str. 2-7)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 931208

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