VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
PDF
  • Ibogaine has sex-specific plasma bioavailability, histopathological and redox/antioxidant effects in rat liver and kidneys [Elektronski vir] : a study on females
    Tatalović, Nikola ...
    Ibogaine induces rapid changes in cellular energetics followed by the elevation of antiox- idant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led ... to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.
    Vir: Life [Elektronski vir]. - ISSN 2075-1729 (Vol. 12, no. 1, Jan. 2022, str. 1-18)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 96210947

    Povezava(-e):

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780973/pdf/life-12-00016.pdf
    Repozitorij Univerze v Ljubljani – RUL
    DOI

Vnos na polico