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  • Targeted sequencing approach : comprehensive analysis of DNA methylation and gene expression across blood and brain regions in suicide victims [Elektronski vir]
    Kouter, Katarina, 1989- ; Zupanc, Tomaž ; Videtič Paska, Alja, 1980-
    Objectives Epigenetic mechanisms are involved in regulation of many pathologies, including suicidal behaviour. However, the factors through which epigenetics affect suicidal behaviour are not fully ... understood. Methods We analysed DNA methylation of eight neuropsychiatric genes (NR3C1, SLC6A4, HTR1A, TPH2, SKA2, MAOA, GABRA1, and NRIP3) in brain regions (hippocampus, insula, amygdala, Brodmann area 46) and blood of 25 male suicide victims and 28 male control subjects, using bisulfite next-generation sequencing. Results Comparing mean methylation values, notable changes were observed in NR3C1 (insula p-value =0.05), HTR1A (insula p-value <0.001, blood p-value =0.001), SKA2 (insula p-value =0.03, blood p-value =0.016), MAOA (blood p-value <0.001), GABRA1 (insula p-value =0.05, blood p-value =0.024) and NRIP3 (hippocampus p-value =0.001, insula p-value =0.002, amygdala p-value =0.014). Comparing methylation pattern between blood and brain, similarity was observed between blood and insula for HTR1A. Gene expression analysis in hippocampus revealed changes in expression of NR3C1 (p-value =0.049), SLC6A4 (p-value =0.017) and HTR1A (p-value =0.053). Conclusions Results provide an insight into the altered state of DNA methylation in suicidal behaviour. Epigenetic differences could therefore affect suicidal behaviour in both previously known and in novel neuropsychiatric candidate genes.
    Vir: The world journal of biological psychiatry [Elektronski vir]. - ISSN 1814-1412 (Vol. 9, 2022, str. 1-12)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 98996483

    Povezava(-e):

    https://www.tandfonline.com/doi/epub/10.1080/15622975.2022.2046291?needAccess=true
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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