Fakulteta za farmacijo, Ljubljana (FFALJ)
  • Influence of desmuramylpeptides from LK-409 series on the cytokine production in the mouse spleen cells
    Sollner Dolenc, Marija ...
    LK-409 (7-oxooctanoyl-l-Ala-d-iGln) was found to modulate immune response. To study the impact of minimal structural changes in the LK-409 molecule on the immunomodulatory activity a series of LK-409 ... analogues was prepared and their activities were evaluated. After the treatment of NmRI mice at a dose of 25 mgdaily for three consecutive days the isolated spleen cells were stimulated with concanavaline A and phorbol 12-myristate 13-acetate (PMA) or ionomycin and PMA, and the production of IL-2, IL-4,-IL-6, IL-10 and IFN-g studied as a function of the different LK-409 analogues. All the compounds modulate the Th1žTh2 cytokine response, especially in the presence of ConA&PMA activation. The minimal structure modification of LK-409 strongly influences the regulation of the cytokine production.
    Vir: Pharmazie. - ISSN 0031-7144 (Vol. 61, no. 10, 2006, str. 866-868)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 1992817

vir: Pharmazie. - ISSN 0031-7144 (Vol. 61, no. 10, 2006, str. 866-868)

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