Fakulteta za farmacijo, Ljubljana (FFALJ)
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PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lungJanžič, Urška ...With introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein ... expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients. We obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of % 5% and % 10% of PD-L1 expression on either TC or IC. 29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC. Our results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC.Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 51, iss. 3, 2017, str. 357-362)Vrsta gradiva - članek, sestavni delLeto - 2017Jezik - angleškiCOBISS.SI-ID - 4381553
Povezava(-e):
https://www.degruyter.com/view/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.xml
https://www.degruyter.com/downloadpdf/j/raon.2017.51.issue-3/raon-2017-0037/raon-2017-0037.pdf
Digitalna knjižnica Slovenije - dLib.si
DiRROS - Digitalni repozitorij raziskovalnih organizacij Slovenije
DOI
Avtor
Janžič, Urška |
Kern, Izidor |
Janžič, Andrej |
Čavka, Luka |
Čufer, Tanja
Teme
Adenokarcinom |
Onkologija |
Imunoterapija |
lung cancer |
squamous-cell lung cancer |
adenocarcinoma |
tumor cells |
immune cells |
PD-L1 expression
Vnos na polico
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Janžič, Urška | |
Kern, Izidor | 15781 |
Janžič, Andrej | 32798 |
Čavka, Luka | 38250 |
Čufer, Tanja | 12179 |
Vir: Osebne bibliografije
in: SICRIS
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