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Obnova občutljivosti v področju prerezanega živca, od strani prišitega na nepoškodovan živec = Recovery of cutaneus pain sensitivity after end-to-side anastomosis of a transected peripheral nerve in the ratKovačič, UrošIf the proximal nerve stump is not available after a peripheral nerve injury, end-to-side anastomosis of its distal stump remains the only treatment modality promising potential recovery of the ... injured nerve's function. Sensoryreturn after end-to-side anastomosis has been investigated in only one study in which the donor nerve was interrupted distally to the anastomosis. There have been no reports on the use of an uninjured donor nerve to date. Thepresent study was undertaken to test the hypothesis that recovery of sensory function of a transected nerve can be induced by using end-to-side anastomosis to an uninjured nerve. The distal stump of the transected peronealnerve was approximated end to side to the intact sural nerve using epineural sutures. Sprouting of sensory axons into the anastomosed peroneal nerve was assessed by the nerve pinch test, and the number of myelinated axonswas determined on a tissue cross-section stained with Azur II. The myelinated axons were counted and their cross-section areas were determined for the sural nerves of both the operated and control animals. Pain sensitivity of the foot instep skin was assessed by the skin pinch test. Over the period of 18 weeks after end-to-side anastomosis of the transected peroneal nerve to the intact sural nerve, the axons sprouted into the peronealnerve in all the 11 animals operated. The pinch test in the anastomosed distal stump of the peroneal was positive in all animals as far asit was possible to test. There were 277+-119 myelinated axons in the anastomosed peroneal nerve, their cross section area being mostly smaller than10 microm2. (Abstract truncated at 2000 characters.)Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 38, [št.] 2, jun. 1999, str. 207-222)Vrsta gradiva - članek, sestavni delLeto - 1999Jezik - slovenskiCOBISS.SI-ID - 10798553
Avtor
Kovačič, Uroš
Teme
Peroneal nerve |
Injuries |
Anatomy and histology |
Sural nerve |
Nerve regeneration |
Axons |
Rats |
Anastomosis, surgical |
Pain measurement |
živci |
periferni živci |
poškodbe |
regeneracija |
kirurško zdravljenje
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vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 38, [št.] 2, jun. 1999, str. 207-222)
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