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  • Alergija za protiepileptična zdravila = Allergy to antiepileptic drugs
    Gradišnik, Peter, 1966- ; Lobnik-Krunič, Brigita
    The symptoms of allergic reactions to antiepileptic drugs (AED) are frequentlyinterlaced with the symptoms of acute pharmacologic adverse effects of AED. Allergic reactions to carbamazepine, ... phenytoin, phenobarbitone and pirimidone are most frequent, while lamotrigine holds first place among the newer AED. The mechanisms of AED allergies proceed according to all four types. Prevalent are milder reactions, most often in the form of skin rash. One percent of allergies are most severe skin reactions resulting in systemic complications. A significant and often overlooked AED allergy, most often occurring in association with an AED of aromatic chemical structure, is the antiepileptic hypersensitivity syndrome (AHS). The diagnostic methods of proving AED allergies are still dificient. Immediate discontinuation of AED atthe onset of an allergic reaction is not associated with a high risk of an epileptic status. The risk of repeated allergic reaction following the introduction of a new drug is not high if we chose a drug that is not chemically related to the chosen initially.
    Vir: Slovenska pediatrija : revija Združenja pediatrov Slovenije in Združenja specialistov šolske in visokošolske medicine Slovenije. - ISSN 1318-4423 (Letn. 7, suppl. 1, 2000, str. 175-178)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11348953

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