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  • Pomen Schwannovih celic za vzdrževanje regeneracije senzoričnih aksonov pri podgani = The role of Schwann cells in maintaining regeneration of sensory axons in the rat
    Gril, Iztok ; Jug, Marko
    Satisfactory regeneration of axons after crush injury of periferal nerve is supported by proliferating Schwann cells (SC) in the distal stump and their basal laminae (BL). SC secrete diffusable ... growth-promoting substances, whereasbasal laminae provide a good growth substratum within the neurilemmal tubes. The results of previous studies of the relative importance of diffusable growth-promoting substances and growth substratum are partly contradictory. A recent study showed that sensory axons regenerating through the acellular distal nerve segment elongated fairly rapidly during the first week after axonotmesis, but then ceased to grow. The leading axons retracted towards the site of axonotmesis. Subsequent elongation was possible only with concurrent migration of SC from the proximal stump. Previous experiments indicated that degeneration of growth substratum in the absence of Schwann cells could be responsible for the cessation of axonal growth. The objective of the study was to examine the following hypotheses: that cessation of axonalgrowth and retraction of sensory axons during the second week of regeneration in the absence of cell support is a consequence of an unfavourable microenviroment of the regenerating axons and is not due to permanent "exhaustion" of the neuron cell body; that, if an adequate growth substratum is maintained, axons continue to grow during the second week even in the absence of SC; and that elongation of axons can be maintained during prolonged regeneration through the acellular distal nerve segment by providingdiffusable growth promoting substances of SC, even though the growth substratum is partly degenerated. In this study, a rat sural nerve was crushed. In the first group of animals, cells in the distal stump were killed by freezing the entire distal segment at once. (Abstract truncated at 2000 characters.)
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 39, št. 2, jun. 2000, str. 135-149)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11824345

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